Inflammation: From Molecular and Cellular Mechanisms to the Clinic

Starting with the molecular basis of inflammation, the book continues with inflammation in infectious diseases and the relationship between inflammation and chronic diseases. The final part of the work is devoted to tissue healing and options for therapeutic interventions. Table of Contents nGO TO PART nExport Citation(s) nFront Matter (Pages: i-xlvi) nCHAPTER 1 nInflammation through the Ages: A Historical Perspective (Pages: 1-16) nJean-Marc Cavaillon nPart One : Inducers and Sensors of Inflammation nCHAPTER 2 nPathogen-associated Molecular Patterns (Pages: 17-56) nJean-Marc Cavaillon nCHAPTER 3 nDamage-associated Molecular Patterns (Pages: 57-80) nJean-Marc Cavaillon nCHAPTER 4 nBacterial Toxins (Pages: 81-98) nMarina de Bernard, Cesare Montecucco nCHAPTER 5 nVenoms (Pages: 99-128) nCatarina Teixeira, Vanessa Moreira, José María Gutiérrez nCHAPTER 6 nHypoxia as an Inducer of Inflammation (Pages: 129-142) nAriel Brandwein, Clifford S. Deutschman nReferences nRequest permissions nCHAPTER 7 nVaccine Adjuvants (Pages: 143-174) nDennis M. Klinman, Hidekazu Shirota nCHAPTER 8 nPattern Recognition Receptors (Pages: 175-216) nLauren Whitehead, Gordon D. Brown nPart Two : Inflammatory Cells nCHAPTER 9 nMonocytes and Macrophages (Pages: 217-252) nIrina N. Shalova, Shilpi Saha, Subhra K. Biswas nCHAPTER 10 nNeutrophils (Pages: 253-272) nSalvatore Cuzzocrea nCHAPTER 11 nMast Cells: Master Drivers of Immune Responses against Pathogens (Pages: 273-288) nW.X. Gladys Ang, Soman N. Abraham nCHAPTER 12 nDendritic Cells in Inflammatory Disease (Pages: 289-314) nBart N. Lambrecht, Martin Guilliams, Hamida Hammad nReferences nRequest permissions nCHAPTER 13 nRoles for NK Cells and ILC1 in Inflammation and Infection (Pages: 315-340) nChristian A.J. Vosshenrich, James P. Di Santo nCHAPTER 14 nGroup 2 and 3 Innate Lymphoid Cells: New Actors in Immunity and Inflammation (Pages: 341-364) nNicolas Serafini, James P. Di Santo nCHAPTER 15 nTh9 Cells: From the Bench to the Bedside and Back Again (Pages: 365-394) nBenjamin J. Ulrich, Matthew M. Hufford, Mark H. Kaplan nCHAPTER 16 nTh17 Cells (Pages: 395-418) nMélissa Noack, Pierre Miossec nCHAPTER 17 nPlatelets (Pages: 419-436) nJack Levin nCHAPTER 18 nEpithelial Cells (Pages: 437-456) nJill M. Hoffman, Charalabos Pothoulakis nReferences nRequest permissions nCHAPTER 19 nInflammation: The Role of Endothelial Cells (Pages: 457-476) nJ. Steven Alexander, D. Neil Granger, Norman R. Harris nPart Three : Inflammatory Mediators nCHAPTER 20 nIL-1 Superfamily and Inflammasome (Pages: 477-528) nCharles A. Dinarello nCHAPTER 21 nTNF Superfamily (Pages: 529-547) nSalvatore Cuzzocrea nCHAPTER 22 nInterleukin-17 A-E (Pages: 549-572) nGiovanni Monteleone, Irene Marafini, Edoardo Troncone nCHAPTER 23 nIL-6 Superfamily (Pages: 573-586) nToshio Tanaka, Masashi Narazaki, Tadamistu Kishimoto nCHAPTER 24 nType I and II Cytokine Superfamilies in Inflammatory Responses (Pages: 587-618) nWilliam F. Carson IV, Steven L. Kunkel nReferences nRequest permissions nCHAPTER 25 nChemokines and Chemotaxis (Pages: 619-650) nOsamu Yoshie, Kouji Matsushima nCHAPTER 26 nLipid Mediators in Inflammation (Pages: 651-694) nShuh Narumiya, Takehiko Yokomizo, Junken Aoki nCHAPTER 27 nFree Radicals in Inflammation (Pages: 695-726) nAndrew Cumpstey, Martin Feelisch nCHAPTER 28 nProteases (Pages: 727-766) nCeline Deraison, Chrystelle Bonnart, Nathalie Vergnolle nCHAPTER 29 nPsychiatric Disorders and Inflammation (Pages: 767-784) nRobert Dantzer nReferences nRequest permissions nCHAPTER 30 nComplement System (Pages: 785-812) nPeter A. Ward, Claudia Kemper nCHAPTER 31 nHeat Shock Proteins (Pages: 813-830) nWillem van Eden, Femke Broere, Ruurd van der Zee nPart Four : Inflammation and Host Response nCHAPTER 32 nInflammation and Coagulation (Pages: 833-860) nMarcel Levi nCHAPTER 33 nFever: Mediators and Mechanisms (Pages: 861-890) nJoachim Roth nCHAPTER 34 nPain (Pages: 891-914) nChristoph Stein nReferences nRequest permissions nCHAPTER 35 nInflammation, Hormones, and Metabolism (Pages: 915-946) nMuska Khpal, Mervyn Singer nCHAPTER 36 nMicroenvironmental Regulation of Innate Immune Cell Function (Pages: 947-970) nEmily R. Watts, Eilise Ryan, Sarah R. Walmsley, Moira K.B. Whyte nCHAPTER 37 nEpigenetics of Inflammation (Pages: 971-992) nVidula Vachharajani, Charles E. McCall nPart Five : Inflammation and Diseases nCHAPTER 38 nAllergy and Inflammation (Pages: 995-1030) nMilena Sokołowska, Anna Głobińska, Cezmi A. Akdis nCHAPTER 39 nSepsis (Pages: 1031-1052) nManu Shankar-Hari, Mervyn Singer nCHAPTER 40 nAutoimmunity and Inflammation (Pages: 1053-1090) nShrikant Ramesh Mulay, Onkar P. Kulkarni, Khader Rupanagudi, Hans-Joachim Anders nReferences nCHAPTER 41 nPsoriasis and Other Skin Inflammatory Diseases (Pages: 1091-1104) nJaehwan Kim, James G. Krueger nCHAPTER 42 nRheumatoid Arthritis and Other Inflammatory Articular Diseases (Pages: 1105-1140) nRogier M. Thurlings, Sander W. Tas, Paul Peter Tak* nCHAPTER 43 nMissing Heritability of Crohn’s Disease and Implications for Therapeutic Targeting and Improved Care (Pages: 1141-1146) nMatthias Chamaillard nCHAPTER 44 nInflammation and Transplantation (Pages: 1147-1172) nWilliam M. Baldwin, III, Robert L. Fairchild nReferences nCHAPTER 45 nInflammatory Mechanisms in Chronic Obstructive Pulmonary Disease (Pages: 1173-1198) nPeter J. Barnes nCHAPTER 46 nObesity: A Complex Disease with Immune Components (Pages: 1199-1224) nYuejun Liu, Karine Clément nCHAPTER 47 nInflammation and Type 2 Diabetes (Pages: 1225-1254) nMarleen M.J. van Greevenbroek, Casper G. Schalkwijk, Coen D.A. Stehouwer nCHAPTER 48 nInflammation-Mediated Neurodegeneration: Models, Mechanisms, and Therapeutic Interventions for Neurodegenerative Diseases (Pages: 1255-1278) nHui-Ming Gao, Yun Gao, Dezhen Tu, Yue Liu, Hui Zhou, Jau-Shyong Hong nCHAPTER 49 nInflammation in Atherosclerosis (Pages: 1279-1300) nMario A.R. Lauterbach, Larisa I. Labzin, Eicke Latz nCHAPTER 50 nAcute Kidney Injury (Pages: 1301-1312) nJohan Mårtensson, Rinaldo Bellomo nReferences nCHAPTER 51 nIschemia–Reperfusion Syndrome (Pages: 1313-1328) nChristophe Adrie, Sally A. Shin, Mehran Monchi nCHAPTER 52 nSingle-Nucleotide Polymorphisms and Inflammation (Pages: 1329-1346) nEvangelos J. Giamarellos-Bourboulis nPart Six : Resolution of Inflammation and Tissue Repair nCHAPTER 53 nPentraxins in the Orchestration of Defense and Tissue Repair during the Acute Phase Response (Pages: 1347-1362) nAlberto Mantovani, Cecilia Garlanda, Barbara Bottazzi nCHAPTER 54 nAnti-Inflammatory Cytokines, Soluble Receptors, and Natural Antagonists (Pages: 1363-1376) nWillem Joost Wiersinga, Tom van der Poll nCHAPTER 55 nRegulatory T Cells (Pages: 1377-1422) nLuciana Berod, Katharina Lahl, Matthias Lochner, Christian T. Mayer, Tim Sparwasser nCHAPTER 56 nLeukocyte Reprogramming (Pages: 1423-1446) nJean-Marc Cavaillon nCHAPTER 57 nRoles of Specialized Proresolving Lipid Mediators in Inflammation Resolution and Tissue Repair (Pages: 1447-1466) nMatthew Spite, Charles N. Serhan nCHAPTER 58 nGlucocorticoids (Pages: 1467-1484) nHeming Nicholas, Annane Djillali nCHAPTER 59 nThe Neuroimmune Communicatome in Inflammation (Pages: 1485-1516) nPeder S. Olofsson, Christine N. Metz, Valentin A. Pavlov nSummary nThe Inflammatory Response in Tissue Repair (Pages: 1517-1538) nNikolaos G. Frangogiannis nPart Seven : Detection and Treatments nCHAPTER 61 nBiomarkers in Inflammation (Pages: 1539-1566) nAndreas Kortgen, Michael Bauer nCHAPTER 62 nIn Vivo Imaging of Inflammation (Pages: 1567-1582) nAnne Roivainen, Antti Saraste nSummary nCHAPTER 63 nNovel Targets for Drug Development (Pages: 1583-1608) nAlan S. Cross, Steven M. Opal nCHAPTER 64 nInflammation and Microbiota and Gut Reconditioning (Pages: 1609-1660) nStig Bengmark nCHAPTER 65 nNatural Products as Source of Anti-Inflammatory Drugs (Pages: 1661-1690) nShivaprasad H. Venkatesha, Bodhraj Acharya, Kamal D. Moudgil About the Author nJean-Marc Cavaillon is professor and Head of the Unit “Cytokines and Inflammation” at Institut Pasteur (Paris). He has been President of the “International Endotoxin and Innate Immunity Society”. He is member of the Editorial Boards of few journals including Shock, Journal of Infectious Diseases, and International Journal of Inflammation, and has been Associate-Editor of “Cytokine” (2002-2009). nJean-Marc Cavaillon has an extensive expertise in innate immunity, particularly on cytokines, inflammation, bacterial endotoxins and other Toll-like receptors agonists, endotoxin tolerance, activation of monocytes/macrophages and neutrophils, altered immune status in sepsis and SIRS patients. He is the co-author of a book “Sepsis and non-infectious inflammation: from biology to critical care” (Wiley VCH, 2009) and the author of a book in French on cytokines (Masson, 1993 & 1996) . Jean-Marc Cavaillon has published 145 scientific articles, 77 reviews and 45 chapters in books. nMervyn Singer is Professor of Intensive Care Medicine at University College London. His primary research interests are sepsis and multi-organ failure, infection, shock and haemodynamic monitoring. Funding for these activities primarily comes from the Wellcome Trust, Medical Research Council and National Institute for Health Research. He developed an oesophageal Doppler haemodynamic monitor that is now in widespread use worldwide, the use of which has been shown in multiple studies to improve outcomes after major surgery and reduce length of stay. He has led on a number of important multi-centre trials in critical care. He has authored various papers and textbooks including the Oxford Handbook of Critical Care, now in its 3rd Edition, and is a Council member of the International Sepsis Forum. He was the first UK intensivist to be awarded Senior Investigator status by the National Institute for Health Research, and to be invited to give plenary lectures at the European and US Intensive Care Congresses.